Cartagena Protocol

Reflections from a Side Event on Gene Drives

To my surprise, the concept of gene drives itself was never properly explained. It was very clear that most people in the room did not understand what gene drives actually are — technologies designed to spread a genetic trait through a population so effectively that it can wipe out an entire species, for example malaria-carrying mosquitoes or invasive rats on islands. Yet, this profound and irreversible aim, nor its potential social and ecological consequences, were ever clarified. Instead, the focus of the event was almost entirely on describing the consultation process between pro–gene-drive researchers and Indigenous participants. The atmosphere was full of mutual compliments and respectful tones — but it felt as if those Indigenous representatives who had serious concerns about gene drives were not present. I later realized that Indigenous Peoples involved in this process had only been in dialogue with researchers promoting the technology, while those scientists warning of its environmental and social risks had never been invited into the discussion.

The process was presented as deeply spiritual, with repeated references to respect for Mother Earth, ethics, spirituality and to listening to each other. While such spirituality is essential, the core issues — how gene-drives may affect life, biodiversity, and cultural or spiritual relationships with the natural world — were never discussed. Spiritual moments were treated as proof of a meaningful process, but spirituality without substance can easily become a tool to mask imbalance.

As the discussion opened, most interventions turned to traditional medicines and past abuses by industry — legitimate concerns, but largely unrelated to the gene drive issue itself. This allowed the facilitator, who was clearly in favor of gene drives, to run out the clock without addressing the deeper risks and ethical questions.

As someone experienced in participatory processes, I could recognize a familiar pattern: when those in power seek “consent,” they often design dialogues that appear inclusive but strategically avoid real debate. The event left me with the strong impression that genuine participation was being replaced by performance — a process meant to legitimize rather than question.

Given how dangerous and irreversible gene drive technologies could be, any claim of Indigenous consent must come from a truly broad and inclusive process — one that actively seeks out and listens to those with deep concerns. Anything less risks turning consultation into complicity.

Intro

Nele Mariën, Friends of the Earth International

Yesterday I attended a side event on gene drives. I am not an expert on the technology, but I do know it is one of the most controversial topics under the Convention on Biological Diversity. My main interest was understanding how dialogue with Indigenous Peoples on this issue would unfold — and whether it would reflect a genuinely participatory process.

ECO 72(8) - Wednesday, 29 October 2025

Targets 2 & 3: Advancing Effective Gender Integration

Alejandra Duarte & Meenal Tatpati, Women4Biodiversity - Biodiversity conservation and restoration, without recognition and legitimisation of women’s consistent efforts cannot be achieved. Yet, women from Indigenous Peoples and local community groups face persistent and systemic barriers including lack of legal and customary access and ownership to land and territories and natural resources, exclusion from funding processes, and marginalization in decision-making spaces which are well established critical areas to achieve conservation outcomes. ...

Corporate invasion of Indigenous territories and infringement of collective rights coincides with biodiversity loss

WilmerLucitante Criollo, UDAPTAround the world, indigenous peoples and local communities are suffering a double attack: on the one hand, extractive projects by transnational companies that devastate their territories and, on the other, human rights violations that occur when they resist. The destruction of biodiversity and the denial of collective rights are two sides of the same coin, both driven by a global economic model that prioritizes investment over human and collective rights and the lives of indigenous communities. ...

Reflections from a Side Event on Gene Drives

Nele MariĂ«n, Friends of the Earth International - Yesterday I attended a side event on gene drives. I am not an expert on the technology, but I do know it is one of the most controversial topics under the Convention on Biological Diversity. My main interest was understanding how dialogue with Indigenous Peoples on this issue would unfold — and whether it would reflect a genuinely participatory process.

Rethinking ecological restoration from the perspective of local communities and their ancestral knowledge

Lizet MejĂ­a, GYBN Peru - In recent years, there has been an increase in initiatives to restore ecosystems in all their diversity, but these lack sufficient information on the contributions of indigenous peoples to restoration.

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Moratorium on genetically engineering wild species in natural ecosystems – IUCN membership split down the middle

Biodiversity is declining at unprecedented rates, driven by human activity that erodes the very foundations of life on Earth. Yet while extinction accelerates, a new trend is emerging: proposals to genetically engineer nature itself. These include eradicating mosquito, mouse or rabbit populations, altering invasive species, making endangered animals disease-resistant, and even reviving extinct creatures like the mammoth or the dire wolf. None has yet succeeded, but the ecological and ethical risks are immense.

The release of genetically engineered organisms into natural ecosystems carries irreversible consequences. Once released, they cannot be recalled. Their interactions with other species are unpredictable, and they could permanently disrupt already fragile ecological networks. The science of ecosystem interactions remains too incomplete to allow confident manipulation, becoming even more unpredictable by the effects of climate change. Moreover, the current biosafety frameworks—designed for crops and livestock—are wholly inadequate for the complexities of wild systems. There are no effective international mechanisms to address cross-border liability or damage.

Another grave concern is that genetic engineering of wild species alters the spiritual, cultural, and ecological connections of Indigenous Peoples’ and Local Communities’ with the ecosystems in their territories, thereby undermining their rights.

Introducing genetic engineering into conservation marks a paradigm shift: from protecting nature for its intrinsic value to redesigning it according to human preferences. Framed as “just another tool,” it risks transforming conservation from safeguarding life to engineering it.

A responsible path forward requires a moratorium—no environmental releases of genetically engineered wild species, not even experimental ones—until science can reliably predict outcomes, strong regulatory systems and global frameworks exist, Indigenous rights are fully respected, and societies have reached broad consensus on ethical boundaries.

Moratoria are not new. They have long been used to prevent irreversible harm, including IUCN’s moratoriums on deep-sea mining and destructive fisheries. Applying the same precautionary logic to genetic engineering of wild species is a vital step to uphold the Precautionary Principle and the intrinsic value of biodiversity.

This need for restraint was recognised in IUCN Motion 133, brought to the IUCN World Conservation Congress in 2025. The motion called for a “precautionary deferment of the release of genetically engineered wild organisms into natural ecosystems.” Although 55% of all members supported it, the motion ultimately failed because the IUCN requires approval from both a majority of organisational members and of government members. Motion 133 fell short of the latter by a single government vote — a narrow margin with far-reaching implications.

It is up to the CBD now to protect against the negative impacts of engineering nature.

More information at https://engineeringnature.org/

Intro

Helena Paul, Econexus

Should IUCN support synthetic biology or oppose it, or remain neutral on its use and potential impacts on nature and nature conservation? A question accompanying IUCN since 2016. Whilst a policy was being devised aiming for neutrality, many members felt that one high risk category should be treated separately.  They made a case for pausing genetically engineered wildlife releases to safeguard nature’s integrity and tabled motion 133.

The message was clear:

Will Gene Drives Work? Cutting Through the Hype in Synthectic Biology

Synthetic biology, drawing on engineering metaphors, has built a vision of “biology by design.” Some practitioners warn that it is often framed as offering “easy solutions to difficult problems” or even as “the one technical solution to many grave world problems.” Engineered gene drives (EGD) for example have attracted considerable attention and funding by promising such simple solutions. The question is whether the science supports these claims.

The ambition: altering nature’s inheritance. Gene drives are designed to bias inheritance so that a chosen genetic trait spreads rapidly through a population — even if it harms the organism. The ambition is to use this mechanism to suppress or eliminate wild species seen as problematic, such as disease-carrying mosquitoes or invasive rodents. But if released, these systems could persist and spread uncontrollably, posing serious ecological risks. Before debating governance, it is worth asking: can they deliver on their promises?

Hype: suggesting readiness that does not exist. One high-profile proposal is to use a “tCRISPR” gene drive to eradicate invasive mice by spreading female infertility. The abstract of the study implies this goal is achievable, but the gene-drive mice used for modeling differ from those actually used in experiments,. It only works in laboratory mice already engineered to express Cas9, meaning it would not function in wild populations. A proof of principle is lacking. Even if such proof were reached, its behavior in nature would remain uncertain due to issues such as drive resistance and mating patterns.

Hype: promising control without proof. Concerns about gene drives spreading uncontrollably are often met with assurances that they can be “localized” or “confined.” “Daisy drives” have been widely cited as the solution, supposedly allowing local control. Yet despite major investment, there is no evidence that a functional daisy drive exists beyond computer models. These assurances rest on hypothetical mechanisms rather than demonstrated technologies.

Hype: overstating novelty by dismissing existing tools. There is a tendency to portray existing control measures as ineffective. A recent gene-drive announcement claimed malaria control had “stalled,” whereas the World Health Organization highlights continuing progress and points to social and funding challenges. This selective framing risks undermining established, proven methods.

Beyond the hype. Promotional terms such as innovative, powerful, and scalable are common in synthetic biology, but assessing real potential requires separating speculation from evidence. As Caulfield notes, the competitive nature of research encourages exaggeration and premature optimism. For gene drives, this means recognizing that what is promised is still far from proven. Whether or not gene drives eventually work, decision-making must be guided by evidence, not hype.

Read the full report Will genedrives work? Cutting through the hype in synthetic biology  on genedrivemonitor.org

Intro

Dr. Ricarda Steinbrecher, Federation of German Scientists

Hype is often part of how scientific development is communicated to decision-makers and the public. As Professor Timothy Caulfield (University of Alberta) explains, “spin happens throughout the science translation process” — from research proposals and peer-reviewed papers to press releases and media stories. Studies confirm a growing use of promotional language, and Caulfield argues that genetics has been particularly prone to this.